Experts Warn Rapid Weight Loss May Accelerate Facial Ageing and Skin Changes

Rapid weight loss associated with bariatric surgery, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and intensive lifestyle changes may lead to significant skin and structural changes, according to a review published in the Journal of Cosmetic Dermatology.

The narrative review examined studies published between 2000 and 2025 investigating the effects of rapid weight loss on soft tissue and body structure.

Researchers reported that rapid intentional weight loss may affect collagen, elastic fibres, adipose tissue, muscle mass and bone integrity. These changes may contribute to loose skin, reduced skin firmness, facial volume loss, muscle reduction and decreased bone density.

The authors said the increasing use of weight-loss medications and bariatric procedures means dermatologists and aesthetic practitioners are likely to see more patients presenting with cosmetic and structural concerns linked to substantial weight reduction.

The review outlined a range of management options, including nutritional support, resistance exercise, energy-based treatments, biostimulatory injectables and surgical intervention in more severe cases.

Emerging regenerative therapies were also discussed, although the authors noted that evidence for these approaches remains limited.

“As rapid weight loss becomes increasingly common, dermatologists are encountering a broader range of cosmetic and structural concerns,” the authors wrote.

“A multidisciplinary, evidence-informed approach is critical for addressing these issues and improving patient outcomes.”